8D8I
Crystal structure of Reverb alpha in complex with synthetic agonist
Summary for 8D8I
Entry DOI | 10.2210/pdb8d8i/pdb |
Descriptor | Nuclear receptor subfamily 1 group D member 1, Nuclear receptor corepressor 1, (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine, ... (4 entities in total) |
Functional Keywords | rev-erb, nuclear receptor, agonist, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 29093.50 |
Authors | Ronin, C.,Ciesielski, F.,Hegazy, L.,Burris, P.T. (deposition date: 2022-06-08, release date: 2022-12-14, Last modification date: 2024-04-03) |
Primary citation | Murray, M.H.,Valfort, A.C.,Koelblen, T.,Ronin, C.,Ciesielski, F.,Chatterjee, A.,Veerakanellore, G.B.,Elgendy, B.,Walker, J.K.,Hegazy, L.,Burris, T.P. Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 13:7131-7131, 2022 Cited by PubMed: 36414641DOI: 10.1038/s41467-022-34892-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.504 Å) |
Structure validation
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