8D6A
Cryo-EM structure of human LIF signaling complex: model containing the interaction core region
Summary for 8D6A
Entry DOI | 10.2210/pdb8d6a/pdb |
EMDB information | 27221 |
Descriptor | Leukemia inhibitory factor, Interleukin-6 receptor subunit beta, Leukemia inhibitory factor receptor, ... (5 entities in total) |
Functional Keywords | cytokine signaling, lif, gp130, lifr, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 186948.84 |
Authors | Zhou, Y.,Franklin, M.C. (deposition date: 2022-06-06, release date: 2023-03-29, Last modification date: 2024-10-09) |
Primary citation | Zhou, Y.,Stevis, P.E.,Cao, J.,Saotome, K.,Wu, J.,Glatman Zaretsky, A.,Haxhinasto, S.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.W.,Olson, W.C.,Franklin, M.C. Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9:eade4395-eade4395, 2023 Cited by PubMed: 36930708DOI: 10.1126/sciadv.ade4395 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.54 Å) |
Structure validation
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