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8D6A

Cryo-EM structure of human LIF signaling complex: model containing the interaction core region

Functional Information from GO Data
ChainGOidnamespacecontents
A0004896molecular_functioncytokine receptor activity
A0016020cellular_componentmembrane
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
D0000902biological_processcell morphogenesis
D0001666biological_processresponse to hypoxia
D0001974biological_processblood vessel remodeling
D0005102molecular_functionsignaling receptor binding
D0005125molecular_functioncytokine activity
D0005146molecular_functionleukemia inhibitory factor receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005829cellular_componentcytosol
D0006955biological_processimmune response
D0007566biological_processembryo implantation
D0008083molecular_functiongrowth factor activity
D0008283biological_processcell population proliferation
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0010467biological_processgene expression
D0010628biological_processpositive regulation of gene expression
D0010646biological_processregulation of cell communication
D0023051biological_processregulation of signaling
D0030225biological_processmacrophage differentiation
D0030324biological_processlung development
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
D0033630biological_processpositive regulation of cell adhesion mediated by integrin
D0035019biological_processsomatic stem cell population maintenance
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0043410biological_processpositive regulation of MAPK cascade
D0045595biological_processregulation of cell differentiation
D0045651biological_processpositive regulation of macrophage differentiation
D0045835biological_processnegative regulation of meiotic nuclear division
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046697biological_processdecidualization
D0046888biological_processnegative regulation of hormone secretion
D0048144biological_processfibroblast proliferation
D0048146biological_processpositive regulation of fibroblast proliferation
D0048286biological_processlung alveolus development
D0048644biological_processmuscle organ morphogenesis
D0048666biological_processneuron development
D0048711biological_processpositive regulation of astrocyte differentiation
D0048861biological_processleukemia inhibitory factor signaling pathway
D0048863biological_processstem cell differentiation
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0060135biological_processmaternal process involved in female pregnancy
D0060426biological_processlung vasculature development
D0060463biological_processlung lobe morphogenesis
D0060707biological_processtrophoblast giant cell differentiation
D0060708biological_processspongiotrophoblast differentiation
D0070373biological_processnegative regulation of ERK1 and ERK2 cascade
D0072108biological_processpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
D0072307biological_processregulation of metanephric nephron tubule epithelial cell differentiation
D0097696biological_processcell surface receptor signaling pathway via STAT
D0140013biological_processmeiotic nuclear division
Functional Information from PROSITE/UniProt
site_idPS00590
Number of Residues20
DetailsLIF_OSM LIF / OSM family signature. SgkdvFQkKklgCqLLgkYK
ChainResidueDetails
DSER173-LYS192

site_idPS01353
Number of Residues51
DetailsHEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsvgsSppskiasmeipnddlkieqvvgmgkgil.......LtWhydPnmtcd....Yv.IkW
ChainResidueDetails
BASN611-TRP661
AASN404-TRP457

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues788
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLN45-SER833
DASN56
DASN85
DASN95
DASN118
DASN138

site_idSWS_FT_FI2
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN64
BASN572
BASN652
BASN663
BASN680
BASN729
BASN787
BASN85
BASN143
BASN191
BASN243
BASN390
BASN445
BASN481
BASN489

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18775332
ChainResidueDetails
BASN131
BASN303
BASN407
BASN426

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20489211
ChainResidueDetails
AASN227

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN379

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:20489211
ChainResidueDetails
AASN383

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN390

222926

PDB entries from 2024-07-24

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