8D6A
Cryo-EM structure of human LIF signaling complex: model containing the interaction core region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004896 | molecular_function | cytokine receptor activity |
| A | 0016020 | cellular_component | membrane |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
| D | 0005102 | molecular_function | signaling receptor binding |
| D | 0005125 | molecular_function | cytokine activity |
| D | 0005146 | molecular_function | leukemia inhibitory factor receptor binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005829 | cellular_component | cytosol |
| D | 0006955 | biological_process | immune response |
| D | 0008083 | molecular_function | growth factor activity |
| D | 0008284 | biological_process | positive regulation of cell population proliferation |
| D | 0010646 | biological_process | regulation of cell communication |
| D | 0023051 | biological_process | regulation of signaling |
| D | 0030154 | biological_process | cell differentiation |
| D | 0030225 | biological_process | macrophage differentiation |
| D | 0033138 | biological_process | positive regulation of peptidyl-serine phosphorylation |
| D | 0033630 | biological_process | positive regulation of cell adhesion mediated by integrin |
| D | 0043410 | biological_process | positive regulation of MAPK cascade |
| D | 0045595 | biological_process | regulation of cell differentiation |
| D | 0045651 | biological_process | positive regulation of macrophage differentiation |
| D | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| D | 0046888 | biological_process | negative regulation of hormone secretion |
| D | 0048861 | biological_process | leukemia inhibitory factor signaling pathway |
| D | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
| D | 0051240 | biological_process | positive regulation of multicellular organismal process |
| D | 0072108 | biological_process | positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| D | 0072307 | biological_process | regulation of metanephric nephron tubule epithelial cell differentiation |
| D | 0097696 | biological_process | cell surface receptor signaling pathway via STAT |
| D | 1904894 | biological_process | positive regulation of receptor signaling pathway via STAT |
| D | 2000026 | biological_process | regulation of multicellular organismal development |
Functional Information from PROSITE/UniProt
| site_id | PS00590 |
| Number of Residues | 20 |
| Details | LIF_OSM LIF / OSM family signature. SgkdvFQkKklgCqLLgkYK |
| Chain | Residue | Details |
| D | SER173-LYS192 |
| site_id | PS01353 |
| Number of Residues | 54 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW |
| Chain | Residue | Details |
| A | ASN404-TRP457 | |
| B | ASN611-TRP661 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8489250","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 91 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 199 |
| Details | Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 95 |
| Details | Domain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18775332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
