8COE
complement C5 in complex with the LCP0195 nanobody
Summary for 8COE
Entry DOI | 10.2210/pdb8coe/pdb |
Descriptor | Complement C5 beta chain, Complement C5 alpha chain, LCP0195, ... (4 entities in total) |
Functional Keywords | innate immunity, complement, terminal pathway, nanobody, antigen-antibody complex, immune system |
Biological source | Lama glama More |
Total number of polymer chains | 3 |
Total formula weight | 200854.66 |
Authors | |
Primary citation | Jindal, S.,Pedersen, D.V.,Gera, N.,Chandler, J.,Patel, R.,Neill, A.,Cone, J.,Zhang, Y.,Yuan, C.X.,Millman, E.E.,Carlin, D.,Puffer, B.,Sheridan, D.,Andersen, G.R.,Tamburini, P. Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration. Mol.Immunol., 165:29-41, 2023 Cited by PubMed: 38142486DOI: 10.1016/j.molimm.2023.12.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.2 Å) |
Structure validation
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