8CI1

Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine

Summary for 8CI1

Entry DOI	10.2210/pdb8ci1/pdb
EMDB information	16665
Descriptor	Neuronal acetylcholine receptor subunit alpha-7, Nanobody E3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	ion channel nanobody nicotinic acetylcholine receptor, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	304100.93
Authors	Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.-J. (deposition date: 2023-02-08, release date: 2023-10-11)
Primary citation	Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.J. An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14:5964-5964, 2023 Cited by PubMed: 37749098 DOI: 10.1038/s41467-023-41734-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation