8CI1

Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC

Chain	Residue	Details
A	CYS127-CYS141

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	415
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	LEU208-PRO232
C	ILE239-ALA257
C	TYR273-TYR294
C	LEU343-ALA363
D	LEU208-PRO232
D	ILE239-ALA257
D	TYR273-TYR294
D	LEU343-ALA363
E	LEU208-PRO232
E	ILE239-ALA257
E	TYR273-TYR294
A	ILE239-ALA257
E	LEU343-ALA363
A	TYR273-TYR294
A	LEU343-ALA363
B	LEU208-PRO232
B	ILE239-ALA257
B	TYR273-TYR294
B	LEU343-ALA363
C	LEU208-PRO232

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site_id	SWS_FT_FI2
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN23
D	ASN23
D	ASN67
D	ASN110
E	ASN23
E	ASN67
E	ASN110
A	ASN67
A	ASN110
B	ASN23
B	ASN67
B	ASN110
C	ASN23
C	ASN67
C	ASN110

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