8CI1
Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | Neuronal acetylcholine receptor subunit alpha-7 | polymer | 388 | 44050.9 | 5 | UniProt (P36544) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | |
| 2 | F, G, H, I, J | Nanobody E3 | polymer | 149 | 15740.2 | 5 | Homo sapiens | ||
| 3 | P, Q, R, S, T | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | E, A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 5 | D, E, A, B, C | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE | non-polymer | 162.2 | 5 | Chemie (NCT) |
Sequence modifications
A, B, C, D, E: 1 - 324 (UniProt: P36544)
A, B, C, D, E: 328 - 375 (UniProt: P36544)
A, B, C, D, E: 328 - 375 (UniProt: P36544)
| PDB | External Database | Details |
|---|---|---|
| Asp 325 | - | linker |
| Gly 326 | - | linker |
| Val 327 | - | linker |
| Ser 376 | - | expression tag |
| Ala 377 | - | expression tag |
| Gly 378 | - | expression tag |
| Leu 379 | - | expression tag |
| Thr 380 | - | expression tag |
| Glu 381 | - | expression tag |
| Thr 382 | - | expression tag |
| Ser 383 | - | expression tag |
| Gln 384 | - | expression tag |
| Val 385 | - | expression tag |
| Ala 386 | - | expression tag |
| Pro 387 | - | expression tag |
| Ala 388 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 298955.7 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2122.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3023.2 | |
| All* | Total formula weight | 304100.9 |
