8BYU

Crystal Structure of HexaBody-CD38 Fab in complex with CD38

Summary for 8BYU

• Entry DOI: 10.2210/pdb8byu/pdb
• Descriptor: Fab Heavy Chain, Fab Light Chain, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, ... (7 entities in total)
• Functional Keywords: cd38, antibody, cdc, hexabody, anti-tumor, antitumor protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 79571.13

Authors

Freier, R.,Krapp, S.,Hibbert, R.G. (deposition date: 2022-12-14, release date: 2023-07-12, Last modification date: 2024-11-20)

Primary citation

Hiemstra, I.H.,Santegoets, K.C.M.,Janmaat, M.L.,De Goeij, B.E.C.G.,Ten Hagen, W.,van Dooremalen, S.,Boross, P.,van den Brakel, J.,Bosgra, S.,Andringa, G.,van Kessel-Welmers, B.,Verzijl, D.,Hibbert, R.G.,Frerichs, K.A.,Mutis, T.,van de Donk, N.W.C.J.,Ahmadi, T.,Satijn, D.,Sasser, A.K.,Breij, E.C.W.
Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity.
Ebiomedicine, 93:104663-104663, 2023

PubMed Abstract: HexaBody®-CD38 (GEN3014) is a hexamerization-enhanced human IgG1 that binds CD38 with high affinity. The E430G mutation in its Fc domain facilitates the natural process of antibody hexamer formation upon binding to the cell surface, resulting in increased binding of C1q and potentiated complement-dependent cytotoxicity (CDC).

PubMed: 37379657
DOI: 10.1016/j.ebiom.2023.104663

Experimental method

X-RAY DIFFRACTION (1.85 Å)