8BYU

Crystal Structure of HexaBody-CD38 Fab in complex with CD38

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Fab Heavy Chain	polymer	235	25112.2	1		Homo sapiens
2	B (L)	Fab Light Chain	polymer	214	23383.9	1		Homo sapiens
3	C (A)	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	polymer	262	30478.5	1	UniProt (P28907) Pfam (PF02267)	Homo sapiens (human)	2'-phospho-ADP-ribosyl cyclase,2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase,2'-phospho-cyclic-ADP-ribose transferase,ADP-ribosyl cyclase 1,ADPRC 1,Cyclic ADP-ribose hydrolase 1,cADPr hydrolase 1,T10
4	D, G, H (H, A)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	E, F (H, L)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	I, J (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7	K, L, M (H, L, A)	water	water		18.0	619	Chemie (HOH)

Sequence modifications

A: 45 - 300 (UniProt: P28907)

PDB	External Database	Details
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
His 44	-	expression tag
Thr 49	Gln 49	conflict
Asp 100	Asn 100	conflict
Ala 164	Asn 164	conflict
Asp 209	Asn 209	conflict
Asp 219	Asn 219	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	78974.6
Non-Polymers*	Number of molecules	7
	Total formula weight	596.5
All*	Total formula weight	79571.1

*Water molecules are not included.