8B92
Crystal structure of PPARG and NCOR2 with an inverse agonist (compound SI-2)
Summary for 8B92
Entry DOI | 10.2210/pdb8b92/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 2, 4-chloranyl-6-fluoranyl-~{N}3-[2-fluoranyl-4-(oxetan-3-yl)phenyl]-~{N}1-[(2-methoxyphenyl)methyl]benzene-1,3-dicarboxamide, ... (5 entities in total) |
Functional Keywords | nuclear hormone receptor transcription factor, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 70071.99 |
Authors | Friberg, A.,Orsi, D.L.,Pook, E.,Siegel, S.,Lemke, C.T.,Stellfeld, T.,Puetter, V.,Goldstein, J. (deposition date: 2022-10-05, release date: 2022-12-28, Last modification date: 2024-05-01) |
Primary citation | Orsi, D.L.,Ferrara, S.J.,Siegel, S.,Friberg, A.,Bouche, L.,Pook, E.,Lienau, P.,Bluck, J.P.,Lemke, C.T.,Akcay, G.,Stellfeld, T.,Meyer, H.,Putter, V.,Holton, S.J.,Korr, D.,Jerchel-Furau, I.,Pantelidou, C.,Strathdee, C.A.,Meyerson, M.,Eis, K.,Goldstein, J.T. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg.Med.Chem., 78:117130-117130, 2022 Cited by PubMed: 36542958DOI: 10.1016/j.bmc.2022.117130 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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