8B7Q
Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement
Summary for 8B7Q
Entry DOI | 10.2210/pdb8b7q/pdb |
Related | 7z3r 8avd |
EMDB information | 15899 |
Descriptor | Leptin, Leptin receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | leptin, lep-r, obesity, metabolism, energy balance, cytokine |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 214053.27 |
Authors | Verstraete, K.,Savvides, S.N.,Verschueren, K.G.,Tsirigotaki, A. (deposition date: 2022-09-30, release date: 2023-04-05, Last modification date: 2023-04-26) |
Primary citation | Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.02 Å) |
Structure validation
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