7ZVX
Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution
Summary for 7ZVX
Entry DOI | 10.2210/pdb7zvx/pdb |
Related | 7ZVN |
Descriptor | Annexin A2, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | nucleic acid binding, aso, antisense oligonucleotide, phosphorothioate, lipid binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 91744.63 |
Authors | Hyjek-Skladanowska, M.,Anderson, B.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Skowronek, K.,Seth, P.,Nowotny, M. (deposition date: 2022-05-17, release date: 2022-09-14, Last modification date: 2024-02-07) |
Primary citation | Hyjek-Skladanowska, M.,Anderson, B.A.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Poznanski, J.T.,Skowronek, K.,Seth, P.,Nowotny, M. Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding. Nucleic Acids Res., 51:1409-1423, 2023 Cited by PubMed: 36124719DOI: 10.1093/nar/gkac774 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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