7ZVN

Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution

7ZVN の概要

• エントリーDOI: 10.2210/pdb7zvn/pdb
• 分子名称: Annexin A2, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: nucleic acid binding, aso, antisense oligonucleotide, phosphorothioate, lipid binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 46780.63

構造登録者

Hyjek-Skladanowska, M.,Anderson, B.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Skowronek, K.,Seth, P.,Nowotny, M. (登録日: 2022-05-16, 公開日: 2022-09-14, 最終更新日: 2024-02-07)

• 主引用文献: Hyjek-Skladanowska, M.,Anderson, B.A.,Mykhaylyk, V.,Orr, C.,Wagner, A.,Poznanski, J.T.,Skowronek, K.,Seth, P.,Nowotny, M.; Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.; Nucleic Acids Res., 51:1409-1423, 2023; PubMed: 36124719; DOI: 10.1093/nar/gkac774

実験手法

X-RAY DIFFRACTION (1.87 Å)