7ZQV

Structure of the SARS-CoV-2 main protease in complex with AG7404

Summary for 7ZQV

Entry DOI	10.2210/pdb7zqv/pdb
Related	7P35 7ZQW
Descriptor	3C-like proteinase nsp5, ethyl (4R)-4-({(2S)-2-[3-{[(5-methyl-1,2-oxazol-3-yl)carbonyl]amino}-2-oxopyridin-1(2H)-yl]pent-4-ynoyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate (3 entities in total)
Functional Keywords	protease, inhibitor, sars-cov-2, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	2
Total formula weight	68702.20
Authors	Fabrega-Ferrer, M.,Herrera-Morande, A.,Perez-Saavedra, J.,Coll, M. (deposition date: 2022-05-03, release date: 2022-12-28, Last modification date: 2024-01-31)
Primary citation	Fabrega-Ferrer, M.,Herrera-Morande, A.,Muriel-Goni, S.,Perez-Saavedra, J.,Bueno, P.,Castro, V.,Garaigorta, U.,Gastaminza, P.,Coll, M. Structure and inhibition of SARS-CoV-1 and SARS-CoV-2 main proteases by oral antiviral compound AG7404. Antiviral Res., 208:105458-105458, 2022 Cited by PubMed: 36336176 DOI: 10.1016/j.antiviral.2022.105458 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation