7ZOG

Crystal structure of Cryptosporidium parvum -Plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor

7ZOG の概要

• エントリーDOI: 10.2210/pdb7zog/pdb
• 分子名称: Lysine-tRNA ligase, LYSINE, 8-[[4-[2-[2-[2-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]sulfonylamino]-~{N}-(cyclohexylmethyl)-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: trna binding, ligase
• 由来する生物種: Cryptosporidium parvum Iowa II
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 249812.81

構造登録者

Dawson, A.,Wyllie, S. (登録日: 2022-04-25, 公開日: 2022-09-07, 最終更新日: 2024-06-19)

• 主引用文献: Milne, R.,Wiedemar, N.,Corpas-Lopez, V.,Moynihan, E.,Wall, R.J.,Dawson, A.,Robinson, D.A.,Shepherd, S.M.,Smith, R.J.,Hallyburton, I.,Post, J.M.,Dowers, K.,Torrie, L.S.,Gilbert, I.H.,Baragana, B.,Patterson, S.,Wyllie, S.; Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.; Acs Infect Dis., 8:1962-1974, 2022; PubMed: 36037410; DOI: 10.1021/acsinfecdis.2c00364

実験手法

X-RAY DIFFRACTION (1.8 Å)