7ZMZ

Engineered Interleukin 2 bound to CD25 receptor

7ZMZ の概要

• エントリーDOI: 10.2210/pdb7zmz/pdb
• 分子名称: Interleukin-2, Interleukin-2 receptor subunit alpha (2 entities in total)
• 機能のキーワード: cytokine receptor, protein engineering, signaling protein, cytokine
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 45837.69

構造登録者

Fyfe, P.K.,Moraga, I.,Gaggero, S.,Mitra, S. (登録日: 2022-04-20, 公開日: 2022-12-14, 最終更新日: 2024-01-31)

• 主引用文献: Gaggero, S.,Martinez-Fabregas, J.,Cozzani, A.,Fyfe, P.K.,Leprohon, M.,Yang, J.,Thomasen, F.E.,Winkelmann, H.,Magnez, R.,Conti, A.G.,Wilmes, S.,Pohler, E.,van Gijsel Bonnello, M.,Thuru, X.,Quesnel, B.,Soncin, F.,Piehler, J.,Lindorff-Larsen, K.,Roychoudhuri, R.,Moraga, I.,Mitra, S.; IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.; Sci Immunol, 7:eade5686-eade5686, 2022; PubMed: 36459543; DOI: 10.1126/sciimmunol.ade5686

実験手法

X-RAY DIFFRACTION (3.2 Å)