7ZHD

Crystal structure of CtaZ in complex with Closthioamide

Summary for 7ZHD

• Entry DOI: 10.2210/pdb7zhd/pdb
• Related: 6WL5
• Descriptor: Transcription activator effector binding, ~{N}-[3-[[3-[3-[3-[3-[(4-hydroxyphenyl)carbothioylamino]propanethioylamino]propanethioylamino]propylamino]-3-sulfanylidene-propyl]amino]-3-sulfanylidene-propyl]-4-oxidanyl-benzenecarbothioamide, ZINC ION, ... (6 entities in total)
• Functional Keywords: gyrase-like domain, receptor, siderophore, self protection, antibiotic resistance, drug binding, lipid binding protein
• Biological source: Ruminiclostridium cellulolyticum
• Total number of polymer chains: 1
• Total formula weight: 18418.26

Authors

Gude, F.,Molloy, E.M.,Horch, T.,Dell, M.,Dunbar, K.L.,Krabbe, J.,Groll, M.,Hertweck, C. (deposition date: 2022-04-06, release date: 2022-11-09, Last modification date: 2024-06-19)

• Primary citation: Gude, F.,Molloy, E.M.,Horch, T.,Dell, M.,Dunbar, K.L.,Krabbe, J.,Groll, M.,Hertweck, C.; A Specialized Polythioamide-Binding Protein Confers Antibiotic Self-Resistance in Anaerobic Bacteria.; Angew.Chem.Int.Ed.Engl., 61:e202206168-e202206168, 2022; PubMed: 35852818; DOI: 10.1002/anie.202206168

Experimental method

X-RAY DIFFRACTION (1.65 Å)