7ZH8

DYRK1a in Complex with a Bromo-Triazolo-Pyridine

Summary for 7ZH8

Entry DOI	10.2210/pdb7zh8/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, CHLORIDE ION, 6-bromanyl-3H-[1,2,3]triazolo[4,5-b]pyridine, ... (11 entities in total)
Functional Keywords	small molecule, kinase, halogen bond, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	185023.29
Authors	Dammann, M.,Stahlecker, J.,Stehle, T.,Boeckler, F.M. (deposition date: 2022-04-05, release date: 2022-11-09, Last modification date: 2024-01-31)
Primary citation	Dammann, M.,Stahlecker, J.,Zimmermann, M.O.,Klett, T.,Rotzinger, K.,Kramer, M.,Coles, M.,Stehle, T.,Boeckler, F.M. Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes. J.Med.Chem., 65:14539-14552, 2022 Cited by PubMed: 36288453 DOI: 10.1021/acs.jmedchem.2c00951 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation