7ZH8
DYRK1a in Complex with a Bromo-Triazolo-Pyridine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 382 | 44553.2 | 4 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
| 2 | E, G, KA, MA, V... (A, C, B, D) | 6-bromanyl-3H-[1,2,3]triazolo[4,5-b]pyridine | non-polymer | 199.0 | 8 | Chemie (IWU) | |||
| 3 | F, LA (A, C) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 4 | H, JA, NA, OA, Y... (A, C, B, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 6 | Chemie (PEG) | |||
| 5 | I, J, RA, ZA (A, C, D) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 6 | AA, BA, CA, K, PA... (B, A, C) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 7 | AB, EA, L, SA (D, B, A, C) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) | |||
| 8 | DA, M (B, A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 2 | Chemie (1PE) | |||
| 9 | BB, CB, DB, FA, GA... (D, B, A, C) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 10 | IA, S, T, U, VA (B, A, C) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 11 | EB, FB, GB, HB (A, B, C, D) | water | water | 18.0 | 519 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 127 - 485 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Met 104 | - | initiating methionine |
| His 105 | - | expression tag |
| His 106 | - | expression tag |
| His 107 | - | expression tag |
| His 108 | - | expression tag |
| His 109 | - | expression tag |
| His 110 | - | expression tag |
| Ser 111 | - | expression tag |
| Ser 112 | - | expression tag |
| Gly 113 | - | expression tag |
| Val 114 | - | expression tag |
| Asp 115 | - | expression tag |
| Leu 116 | - | expression tag |
| Gly 117 | - | expression tag |
| Thr 118 | - | expression tag |
| Glu 119 | - | expression tag |
| Asn 120 | - | expression tag |
| Leu 121 | - | expression tag |
| Tyr 122 | - | expression tag |
| Phe 123 | - | expression tag |
| Gln 124 | - | expression tag |
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 178212.8 | |
| Non-Polymers* | Number of molecules | 52 |
| Total formula weight | 6810.5 | |
| All* | Total formula weight | 185023.3 |
