7ZDQ

Cryo-EM structure of Human ACE2 bound to a high-affinity SARS CoV-2 mutant

Summary for 7ZDQ

Entry DOI	10.2210/pdb7zdq/pdb
EMDB information	14666
Descriptor	Processed angiotensin-converting enzyme 2, Spike protein S1, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	sars cov-2, rbd, ace2, viral protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	100053.85
Authors	Bate, N.,Savva, C.G.,Moody, P.C.E.,Brown, E.A.,Schwabe, W.R.,Brindle, N.P.J.,Ball, J.K.,Sale, J.E. (deposition date: 2022-03-29, release date: 2022-05-18, Last modification date: 2022-08-10)
Primary citation	Bate, N.,Savva, C.G.,Moody, P.C.E.,Brown, E.A.,Evans, S.E.,Ball, J.K.,Schwabe, J.W.R.,Sale, J.E.,Brindle, N.P.J. In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding. Plos Pathog., 18:e1010733-e1010733, 2022 Cited by PubMed: 35849637 DOI: 10.1371/journal.ppat.1010733 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation