7ZAN

Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC

Summary for 7ZAN

• Entry DOI: 10.2210/pdb7zan/pdb
• Related: 5N9B
• Descriptor: Interleukin-17A, Interleukin-17 receptor A, Isoform 2 of Interleukin-17 receptor C, ... (4 entities in total)
• Functional Keywords: immune system, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 113872.49

Authors

Rondeau, J.M.,Goepfert, A. (deposition date: 2022-03-22, release date: 2022-10-12, Last modification date: 2024-01-31)

• Primary citation: Goepfert, A.,Barske, C.,Lehmann, S.,Wirth, E.,Willemsen, J.,Gudjonsson, J.E.,Ward, N.L.,Sarkar, M.K.,Hemmig, R.,Kolbinger, F.,Rondeau, J.M.; IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.; Cell Rep, 41:111489-111489, 2022; PubMed: 36260993; DOI: 10.1016/j.celrep.2022.111489

Experimental method

X-RAY DIFFRACTION (5.061 Å)