7ZAN

Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin-17A	polymer	123	14177.9	2	UniProt (Q16552) Pfam (PF06083)	Homo sapiens (human)	IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8
2	C (C)	Interleukin-17 receptor A	polymer	292	34073.6	1	UniProt (Q96F46) Pfam (PF16556) Pfam (PF16578)	Homo sapiens (human)	IL-17 receptor A,IL-17RA,CDw217
3	D (D)	Isoform 2 of Interleukin-17 receptor C	polymer	453	50558.3	1	UniProt (Q8NAC3) Pfam (PF15037)	Homo sapiens (human)	IL-17 receptor C,IL-17RC,Interleukin-17 receptor homolog,IL17Rhom,Interleukin-17 receptor-like protein,IL-17RL,ZcytoR14
4	E, F, G, H (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B: 34 - 155 (UniProt: Q16552)

PDB	External Database	Details
Gly 33	-	expression tag
Asp 68	Asn 68	engineered mutation
Ser 129	Cys 129	engineered mutation

C: 33 - 320 (UniProt: Q96F46)

PDB	External Database	Details
Asp 49	Asn 49	engineered mutation
Asp 206	Asn 206	engineered mutation
Asp 265	Asn 265	engineered mutation
Glu 321	-	expression tag
Phe 322	-	expression tag
Arg 323	-	expression tag
His 324	-	expression tag

D: 21 - 467 (UniProt: Q8NAC3)

PDB	External Database	Details
Arg 307	Gln 307	conflict
Glu 468	-	expression tag
Phe 469	-	expression tag
Arg 470	-	expression tag
His 471	-	expression tag
Asp 472	-	expression tag
Ser 473	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112987.7
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	113872.5

*Water molecules are not included.