7ZAN
Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Interleukin-17A | polymer | 123 | 14177.9 | 2 | UniProt (Q16552) Pfam (PF06083) In PDB | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
2 | C | Interleukin-17 receptor A | polymer | 292 | 34073.6 | 1 | UniProt (Q96F46) Pfam (PF16556) Pfam (PF16578) In PDB | Homo sapiens (human) | IL-17 receptor A,IL-17RA,CDw217 |
3 | D | Isoform 2 of Interleukin-17 receptor C | polymer | 453 | 50558.3 | 1 | UniProt (Q8NAC3) Pfam (PF15037) In PDB | Homo sapiens (human) | IL-17 receptor C,IL-17RC,Interleukin-17 receptor homolog,IL17Rhom,Interleukin-17 receptor-like protein,IL-17RL,ZcytoR14 |
4 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B: 34 - 155 (UniProt: Q16552)
C: 33 - 320 (UniProt: Q96F46)
D: 21 - 467 (UniProt: Q8NAC3)
PDB | External Database | Details |
---|---|---|
Gly 33 | - | expression tag |
Asp 68 | Asn 68 | engineered mutation |
Ser 129 | Cys 129 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asp 49 | Asn 49 | engineered mutation |
Asp 206 | Asn 206 | engineered mutation |
Asp 265 | Asn 265 | engineered mutation |
Glu 321 | - | expression tag |
Phe 322 | - | expression tag |
Arg 323 | - | expression tag |
His 324 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Arg 307 | Gln 307 | conflict |
Glu 468 | - | expression tag |
Phe 469 | - | expression tag |
Arg 470 | - | expression tag |
His 471 | - | expression tag |
Asp 472 | - | expression tag |
Ser 473 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 112987.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 884.8 | |
All* | Total formula weight | 113872.5 |