7Z9P

The novel DNA binding mechanism of ridinilazole, a precision Clostridiodes difficile antibiotic

Summary for 7Z9P

• Entry DOI: 10.2210/pdb7z9p/pdb
• Descriptor: DNA (5'-D(P*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G*(RID))-3'), Ridinilazole, SULFATE ION, ... (6 entities in total)
• Functional Keywords: clostridiodes difficile, antibiotic, dna-binding, drug discovery, target identification, dna
• Biological source: synthetic construct (32630)
• Total number of polymer chains: 6
• Total formula weight: 23845.16

Authors

Mason, S.,Leonard, P.M. (deposition date: 2022-03-21, release date: 2023-03-29, Last modification date: 2024-02-07)

• Primary citation: Mason, C.S.,Avis, T.,Hu, C.,Nagalingam, N.,Mudaliar, M.,Coward, C.,Begum, K.,Gajewski, K.,Alam, M.J.,Basseres, E.,Moss, S.,Reich, S.,Duperchy, E.,Fox, K.R.,Garey, K.W.,Powell, D.J.; The Novel DNA Binding Mechanism of Ridinilazole, a Precision Clostridiodes difficile Antibiotic.; Antimicrob.Agents Chemother., 67:e0156322-e0156322, 2023; PubMed: 37093023; DOI: 10.1128/aac.01563-22

Experimental method

X-RAY DIFFRACTION (2.2 Å)