7Z1K

Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA polymerase II CTD heptapeptide phosphorylated on Ser5

7Z1K の概要

• エントリーDOI: 10.2210/pdb7z1k/pdb
• 分子名称: Msx2-interacting protein, SER-TYR-SER-PRO-THR-SEP (3 entities in total)
• 機能のキーワード: human sharp, spoc domain, rna polymerase ii ctd heptapeptide, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20452.40

構造登録者

Appel, L.,Grishkovskaya, I.,Slade, D.,Djinovic-Carugo, K. (登録日: 2022-02-24, 公開日: 2022-12-07, 最終更新日: 2024-02-07)

• 主引用文献: Appel, L.M.,Franke, V.,Benedum, J.,Grishkovskaya, I.,Strobl, X.,Polyansky, A.,Ammann, G.,Platzer, S.,Neudolt, A.,Wunder, A.,Walch, L.,Kaiser, S.,Zagrovic, B.,Djinovic-Carugo, K.,Akalin, A.,Slade, D.; The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.; Nat Commun, 14:166-166, 2023; PubMed: 36631525; DOI: 10.1038/s41467-023-35853-1

実験手法

X-RAY DIFFRACTION (1.55 Å)