7YYN

Mammalian Dicer in the dicing state with pre-miR-15a substrate

Summary for 7YYN

• Entry DOI: 10.2210/pdb7yyn/pdb
• EMDB information: 14384
• Descriptor: 59-nt precursor of miR-15a, Isoform 2 of Endoribonuclease Dicer (2 entities in total)
• Functional Keywords: endoribonuclease, dsrna, complex, gene silencing, post-transcriptional, catalytic complex, cytoplasm, rna binding protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 219058.22

Authors

Zanova, M.,Zapletal, D.,Kubicek, K.,Stefl, R.,Pinkas, M.,Novacek, J. (deposition date: 2022-02-18, release date: 2022-11-16, Last modification date: 2024-07-17)

• Primary citation: Zapletal, D.,Taborska, E.,Pasulka, J.,Malik, R.,Kubicek, K.,Zanova, M.,Much, C.,Sebesta, M.,Buccheri, V.,Horvat, F.,Jenickova, I.,Prochazkova, M.,Prochazka, J.,Pinkas, M.,Novacek, J.,Joseph, D.F.,Sedlacek, R.,Bernecky, C.,O'Carroll, D.,Stefl, R.,Svoboda, P.; Structural and functional basis of mammalian microRNA biogenesis by Dicer.; Mol.Cell, 82:4064-4079.e13, 2022; PubMed: 36332606; DOI: 10.1016/j.molcel.2022.10.010

Experimental method

ELECTRON MICROSCOPY (6.21 Å)