7YXC

Crystal structure of WT AncGR2-LBD bound to dexamethasone and SHP coregulator fragment

Summary for 7YXC

Entry DOI	10.2210/pdb7yxc/pdb
Descriptor	Ancestral Glucocorticoid Receptor2, SHP NR Box 1 Peptide, DEXAMETHASONE, ... (6 entities in total)
Functional Keywords	nuclear receptor, transcription factor, dexamethasone, nuclear receptor subfamily 0 group b member 2, nuclear protein
Biological source	unidentified More
Total number of polymer chains	2
Total formula weight	30560.51
Authors	Jimenez-Panizo, A.,Estebanez-Perpina, E.,Fuentes-Prior, P. (deposition date: 2022-02-15, release date: 2022-12-07, Last modification date: 2024-01-31)
Primary citation	Jimenez-Panizo, A.,Alegre-Marti, A.,Tettey, T.T.,Fettweis, G.,Abella, M.,Anton, R.,Johnson, T.A.,Kim, S.,Schiltz, R.L.,Nunez-Barrios, I.,Font-Diaz, J.,Caelles, C.,Valledor, A.F.,Perez, P.,Rojas, A.M.,Fernandez-Recio, J.,Presman, D.M.,Hager, G.L.,Fuentes-Prior, P.,Estebanez-Perpina, E. The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities. Nucleic Acids Res., 50:13063-13082, 2022 Cited by PubMed: 36464162 DOI: 10.1093/nar/gkac1119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation