7YX8

Crystal structure of the AM0627 (E326A) inactive mutant in complex with PSGL-1-like bis-T glycopeptide and Zn2+

Summary for 7YX8

Entry DOI	10.2210/pdb7yx8/pdb
Descriptor	Peptidase M60 domain-containing protein, PSGL-1-like bis-T glycopeptide, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose, ... (6 entities in total)
Functional Keywords	glycoprotease, mucinase, t antigen, tn antigen, am0627, hydrolase
Biological source	Akkermansia muciniphila More
Total number of polymer chains	4
Total formula weight	104512.30
Authors	Taleb, V.,Liao, Q.,Narimatsu, Y.,Garcia-Garcia, A.,Companon, I.,Borges, R.J.,Gonzalez-Ramirez, A.M.,Corzana, F.,Clausen, H.,Rovira, C.,Hurtado-Guerrero, R. (deposition date: 2022-02-15, release date: 2022-07-20, Last modification date: 2022-08-10)
Primary citation	Taleb, V.,Liao, Q.,Narimatsu, Y.,Garcia-Garcia, A.,Companon, I.,Borges, R.J.,Gonzalez-Ramirez, A.M.,Corzana, F.,Clausen, H.,Rovira, C.,Hurtado-Guerrero, R. Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut. Nat Commun, 13:4324-4324, 2022 Cited by PubMed: 35882872 DOI: 10.1038/s41467-022-32021-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation