7YV4

Crystal structure of human UCHL3 in complex with Farrerol

7YV4 の概要

• エントリーDOI: 10.2210/pdb7yv4/pdb
• 分子名称: Ubiquitin carboxyl-terminal hydrolase isozyme L3, (2~{S})-2-(4-hydroxyphenyl)-6,8-dimethyl-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one (3 entities in total)
• 機能のキーワード: activator, complex, ubiquitinase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26513.88

構造登録者

Mao, Z.Y.,Xu, X.J.,Zhang, W.T. (登録日: 2022-08-18, 公開日: 2023-04-19, 最終更新日: 2023-11-29)

• 主引用文献: Zhang, W.,Wang, M.,Song, Z.,Fu, Q.,Chen, J.,Zhang, W.,Gao, S.,Sun, X.,Yang, G.,Zhang, Q.,Yang, J.,Tang, H.,Wang, H.,Kou, X.,Wang, H.,Mao, Z.,Xu, X.,Gao, S.,Jiang, Y.; Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.; Nat Commun, 14:1838-1838, 2023; PubMed: 37012254; DOI: 10.1038/s41467-023-37576-9

実験手法

X-RAY DIFFRACTION (1.58 Å)