7YQE

Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54.

7YQE の概要

• エントリーDOI: 10.2210/pdb7yqe/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src,KiSS-1 receptor (1 entity in total)
• 機能のキーワード: protein kinase-like, signaling, complex, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42809.82

構造登録者

Song, G.,Xu, S. (登録日: 2022-08-06, 公開日: 2023-08-16, 最終更新日: 2024-02-28)

• 主引用文献: Li, Z.,Yang, X.,Fu, R.,Wu, Z.,Xu, S.,Jiao, J.,Qian, M.,Zhang, L.,Wu, C.,Xie, T.,Yao, J.,Wu, Z.,Li, W.,Ma, G.,You, Y.,Chen, Y.,Zhang, H.K.,Cheng, Y.,Tang, X.,Wu, P.,Lian, G.,Wei, H.,Zhao, J.,Xu, J.,Ai, L.,Siwko, S.,Wang, Y.,Ding, J.,Song, G.,Luo, J.,Liu, M.,Xiao, J.; Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.; Nat Commun, 15:1300-1300, 2024; PubMed: 38346942; DOI: 10.1038/s41467-024-44852-9

実験手法

X-RAY DIFFRACTION (3.5 Å)