7YQ8
Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide
Summary for 7YQ8
Entry DOI | 10.2210/pdb7yq8/pdb |
EMDB information | 34022 |
Descriptor | DNA topoisomerase 2-beta, 50-mer DNA, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | topoisomerase, etoposide, dna, isomerase, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 429939.50 |
Authors | Naganuma, M.,Ehara, H.,Kim, D.,Nakagawa, R.,Cong, A.,Bu, H.,Jeong, J.,Jang, J.,Schellenberg, M.J.,Bunch, H.,Sekine, S. (deposition date: 2022-08-05, release date: 2024-01-03) |
Primary citation | Bunch, H.,Kim, D.,Naganuma, M.,Nakagawa, R.,Cong, A.,Jeong, J.,Ehara, H.,Vu, H.,Chang, J.H.,Schellenberg, M.J.,Sekine, S.I. ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes. Nat Commun, 14:8341-8341, 2023 Cited by PubMed: 38097570DOI: 10.1038/s41467-023-44089-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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