7YPZ

Zafirlukast in complex with CRM1-Ran-RanBP1

Summary for 7YPZ

• Entry DOI: 10.2210/pdb7ypz/pdb
• Descriptor: GTP-binding nuclear protein Ran, GLYCEROL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ... (13 entities in total)
• Functional Keywords: active ran, complex, transport protein, inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 158591.94

Authors

Sun, Q.,Lei, Y. (deposition date: 2022-08-05, release date: 2023-08-16, Last modification date: 2024-05-08)

• Primary citation: Huang, W.,Wang, J.X.,Shen, X.,Lei, Y.,Chen, X.,Jia, D.,Zhang, X.,Sun, Q.; Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach.; J.Med.Chem., 66:1574-1582, 2023; PubMed: 36622814; DOI: 10.1021/acs.jmedchem.2c01772

Experimental method

X-RAY DIFFRACTION (2.15 Å)