7YC5

Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody

Summary for 7YC5

• Entry DOI: 10.2210/pdb7yc5/pdb
• EMDB information: 33734
• Descriptor: Spike glycoprotein, Bispecific anitybody (scFv and light chain of the antibody), Heavy chain from K202.B antibody, ... (4 entities in total)
• Functional Keywords: spike protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 9
• Total formula weight: 706901.50

Authors

Yoo, Y.,Cho, H.S. (deposition date: 2022-06-30, release date: 2023-07-05, Last modification date: 2025-03-05)

• Primary citation: Kim, J.W.,Heo, K.,Kim, H.J.,Yoo, Y.,Cho, H.S.,Jang, H.J.,Lee, H.Y.,Ko, I.Y.,Woo, J.R.,Cho, Y.B.,Lee, J.H.,Yang, H.R.,Shin, H.G.,Choi, H.L.,Hwang, K.,Kim, S.,Kim, H.,Chun, K.,Lee, S.; Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants; Antiviral Res., 212:105576-, 2023; DOI: 10.1016/j.antiviral.2023.105576

Experimental method

ELECTRON MICROSCOPY (3.1 Å)