7YC5
Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein | polymer | 1208 | 133781.3 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D, E, F (D, E, F) | Bispecific anitybody (scFv and light chain of the antibody) | polymer | 478 | 49646.2 | 3 | Homo sapiens | ||
| 3 | G, H, I (G, H, I) | Heavy chain from K202.B antibody | polymer | 454 | 49846.8 | 3 | Homo sapiens | ||
| 4 | AA, BA, CA, DA, EA... (B, C, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 32 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 1208 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 682 | Arg 682 | engineered mutation |
| Ser 683 | Arg 683 | engineered mutation |
| Ser 685 | Arg 685 | engineered mutation |
| Pro 817 | Phe 817 | engineered mutation |
| Pro 892 | Ala 892 | engineered mutation |
| Pro 899 | Ala 899 | engineered mutation |
| Pro 942 | Ala 942 | engineered mutation |
| Pro 986 | Lys 986 | engineered mutation |
| Pro 987 | Val 987 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 699822.8 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 7078.7 | |
| All* | Total formula weight | 706901.5 |
