7YB7

anti-apoptotic protein BCL-2-M12

Summary for 7YB7

• Entry DOI: 10.2210/pdb7yb7/pdb
• Descriptor: Apoptosis regulator Bcl-2,Bcl-2-like protein 1, cp2 peptide, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide, ... (4 entities in total)
• Functional Keywords: bcl-2, m12 mutants, anti-apoptotic, cyclic peptide, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 38628.75

Authors

Li, F.W.,Liu, C.,Wu, D.L. (deposition date: 2022-06-29, release date: 2023-11-15, Last modification date: 2024-02-28)

• Primary citation: Li, F.,Liu, J.,Liu, C.,Liu, Z.,Peng, X.,Huang, Y.,Chen, X.,Sun, X.,Wang, S.,Chen, W.,Xiong, D.,Diao, X.,Wang, S.,Zhuang, J.,Wu, C.,Wu, D.; Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.; Nat Commun, 15:1476-1476, 2024; PubMed: 38368459; DOI: 10.1038/s41467-024-45848-1

Experimental method

X-RAY DIFFRACTION (2.2 Å)