7YB7

anti-apoptotic protein BCL-2-M12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Apoptosis regulator Bcl-2,Bcl-2-like protein 1	polymer	153	17593.4	2	UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (human)	Bcl2-L-1,Apoptosis regulator Bcl-X
2	C, D (C, D)	cp2 peptide	polymer	11	1429.6	2		Homo sapiens
3	E, F (C, D)	N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide	non-polymer		291.4	2	Chemie (IQ8)
4	G, H, I, J (A, B, C, D)	water	water		18.0	261	Chemie (HOH)

Sequence modifications

A, B: 2 - 27 (UniProt: P10415)

PDB	External Database	Details
Met 1	-	initiating methionine
Ser 12	His 20	engineered mutation

A, B: 28 - 41 (UniProt: Q07817)
A, B: 42 - 153 (UniProt: P10415)

PDB	External Database	Details
Gln 45	Leu 95	engineered mutation
Leu 56	Arg 106	engineered mutation
Gly 74	Phe 124	engineered mutation
Tyr 77	Arg 127	engineered mutation
Ala 78	Gly 128	engineered mutation
Ser 79	Arg 129	engineered mutation
Val 118	Pro 168	engineered mutation
Ala 125	Leu 175	engineered mutation
Ala 128	Thr 178	engineered mutation
Thr 129	Glu 179	engineered mutation
Asp 133	Arg 183	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	38046.0
Non-Polymers*	Number of molecules	2
	Total formula weight	582.7
All*	Total formula weight	38628.8

*Water molecules are not included.