7YB7
anti-apoptotic protein BCL-2-M12
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Apoptosis regulator Bcl-2,Bcl-2-like protein 1 | polymer | 153 | 17593.4 | 2 | UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
2 | C, D | cp2 peptide | polymer | 11 | 1429.6 | 2 | Homo sapiens | ||
3 | C, D | N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide | non-polymer | 291.4 | 2 | Chemie (IQ8) | |||
4 | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 27 (UniProt: P10415)
A, B: 28 - 41 (UniProt: Q07817)
A, B: 42 - 153 (UniProt: P10415)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ser 12 | His 20 | engineered mutation |
A, B: 42 - 153 (UniProt: P10415)
PDB | External Database | Details |
---|---|---|
Gln 45 | Leu 95 | engineered mutation |
Leu 56 | Arg 106 | engineered mutation |
Gly 74 | Phe 124 | engineered mutation |
Tyr 77 | Arg 127 | engineered mutation |
Ala 78 | Gly 128 | engineered mutation |
Ser 79 | Arg 129 | engineered mutation |
Val 118 | Pro 168 | engineered mutation |
Ala 125 | Leu 175 | engineered mutation |
Ala 128 | Thr 178 | engineered mutation |
Thr 129 | Glu 179 | engineered mutation |
Asp 133 | Arg 183 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 38046.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 582.7 | |
All* | Total formula weight | 38628.8 |