7Y1G

Crystal structure of human PRKACA complexed with DS01080522

7Y1G の概要

• エントリーDOI: 10.2210/pdb7y1g/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, 1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: serine/threonine protein kinase, protein kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82625.22

構造登録者

Suzuki, M.,Ubukata, O.,Toyoda, A. (登録日: 2022-06-08, 公開日: 2022-09-28, 最終更新日: 2024-04-03)

• 主引用文献: Toyota, A.,Goto, M.,Miyamoto, M.,Nagashima, Y.,Iwasaki, S.,Komatsu, T.,Momose, T.,Yoshida, K.,Tsukada, T.,Matsufuji, T.,Ohno, A.,Suzuki, M.,Ubukata, O.,Kaneta, Y.; Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model.; Biochem.Biophys.Res.Commun., 621:157-161, 2022; PubMed: 35839742; DOI: 10.1016/j.bbrc.2022.07.008

実験手法

X-RAY DIFFRACTION (2.3 Å)