7XVZ

Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-3-(2-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propanenitrile

Summary for 7XVZ

• Entry DOI: 10.2210/pdb7xvz/pdb
• Related: 7XVY
• Descriptor: Estrogen receptor beta, SRC peptide, (2~{R})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile, ... (4 entities in total)
• Functional Keywords: inhibitor, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 58725.77

Authors

Furuya, N.,Handa, C. (deposition date: 2022-05-25, release date: 2022-07-20, Last modification date: 2023-11-29)

• Primary citation: Handa, C.,Yamazaki, Y.,Yonekubo, S.,Furuya, N.,Momose, T.,Ozawa, T.,Furuishi, T.,Fukuzawa, K.,Yonemochi, E.; Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with diarylpropionitrile (DPN) or DPN derivatives.; J.Steroid Biochem.Mol.Biol., 222:106152-106152, 2022; PubMed: 35810932; DOI: 10.1016/j.jsbmb.2022.106152

Experimental method

X-RAY DIFFRACTION (2.08 Å)