7XVZ

Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-3-(2-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propanenitrile

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Estrogen receptor beta	polymer	247	27702.6	2	UniProt (Q92731) Pfam (PF00104) In PDB	Homo sapiens (human)	ER-beta,Nuclear receptor subfamily 3 group A member 2
2	C, D	SRC peptide	polymer	13	1386.6	2	UniProt (by SIFTS) (Q15788) In PDB	Homo sapiens
3	A, B	(2~{R})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile	non-polymer		273.7	2	Chemie (I1D)
4		water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B: 261 - 500 (UniProt: Q92731)

PDB	External Database	Details
Gly 256	-	expression tag
Pro 257	-	expression tag
Leu 258	-	expression tag
Gly 259	-	expression tag
Ser 260	-	expression tag
Ser 334	Cys 334	engineered mutation
Ser 369	Cys 369	engineered mutation
Ser 481	Cys 481	engineered mutation
Asp 501	-	expression tag
Asp 502	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	58178.3
Non-Polymers*	Number of molecules	2
	Total formula weight	547.4
All*	Total formula weight	58725.8

*Water molecules are not included.