7XRR

Crystal structure of the human OX2R bound to the insomnia drug lemborexant.

Summary for 7XRR

• Entry DOI: 10.2210/pdb7xrr/pdb
• Descriptor: Orexin receptor type 2, (1~{R},2~{S})-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-~{N}-(5-fluoranylpyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide (2 entities in total)
• Functional Keywords: gpcr, insomnia drug, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39972.32

Authors

Asada, H.,Im, D.,Iwata, S. (deposition date: 2022-05-11, release date: 2022-11-23, Last modification date: 2023-11-29)

• Primary citation: Asada, H.,Im, D.,Hotta, Y.,Yasuda, S.,Murata, T.,Suno, R.,Iwata, S.; Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.; Structure, 30:1582-1589.e4, 2022; PubMed: 36417909; DOI: 10.1016/j.str.2022.11.001

Experimental method

X-RAY DIFFRACTION (2.89 Å)