7XRR
Crystal structure of the human OX2R bound to the insomnia drug lemborexant.
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSVwTLSAIALDRWYaI |
| Chain | Residue | Details |
| A | VAL140-ILE156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | TRP55-VAL75 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 91 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | CYS76-VAL88 | |
| A | ASP151-ARG170 | |
| A | LEU244-HIS335 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | THR89-ALA110 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 61 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | THR111-CYS127 | |
| A | GLU192-MET222 | |
| A | ALA358-GLU373 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | LYS128-LEU150 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | ASN171-MET191 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | TYR223-TYR243 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | THR336-SER357 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:25533960 |
| Chain | Residue | Details |
| A | GLU374-VAL397 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25533960, ECO:0007744|PDB:4S0V |
| Chain | Residue | Details |
| A | ALA355 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Important for responses to orexin => ECO:0000269|PubMed:26950369 |
| Chain | Residue | Details |
| A | TRP44 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN202 |
