7XKJ

Kras-G12D-GDP-MRTX1133 by FIB-MicroED

Summary for 7XKJ

• Entry DOI: 10.2210/pdb7xkj/pdb
• Descriptor: KRAS proto-oncogene, GTPase, GUANOSINE-5'-DIPHOSPHATE, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, ... (5 entities in total)
• Functional Keywords: oncoprotein, g12d, gdp, gtpase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor, microed
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20381.87

Authors

Li, X.M. (deposition date: 2022-04-19, release date: 2023-08-02, Last modification date: 2023-08-16)

• Primary citation: Li, X.M.; Kras-G12D-GDP-MRTX1133 by FIB-MicroED; To Be Published,

Experimental method

ELECTRON CRYSTALLOGRAPHY (3 Å)