7XKJ
Kras-G12D-GDP-MRTX1133 by FIB-MicroED
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | KRAS proto-oncogene, GTPase | polymer | 169 | 19313.7 | 1 | UniProt (A0A7J7Z4L6) Pfam (PF00071) | Homo sapiens (human) | |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 3 | C (A) | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol | non-polymer | 600.6 | 1 | Chemie (6IC) PubChem (177366592) PubChem (162369732) PubChem (166603898) PubChem (166607374) PubChem (169273440) PubChem (169410089) PubChem (171346253) PubChem (172156090) PubChem (156124857) PubChem (166080707) PubChem (169041315) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: A0A7J7Z4L6)
| PDB | External Database | Details |
|---|---|---|
| Asp 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19313.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1068.1 | |
| All* | Total formula weight | 20381.9 |
