7XKJ
Kras-G12D-GDP-MRTX1133 by FIB-MicroED
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | KRAS proto-oncogene, GTPase | polymer | 169 | 19313.7 | 1 | UniProt (A0A7J7Z4L6) Pfam (PF00071) | Homo sapiens (human) | |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (A) | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol | non-polymer | 600.6 | 1 | Chemie (6IC) PubChem (162369732) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: A0A7J7Z4L6)
| PDB | External Database | Details |
|---|---|---|
| Asp 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19313.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1068.1 | |
| All* | Total formula weight | 20381.9 |
