7XJF

Crystal structure of 6MW3211 Fab in complex with CD47

Summary for 7XJF

• Entry DOI: 10.2210/pdb7xjf/pdb
• Descriptor: Heavy chain of 6MW3211 Fab, Light chain of 6MW3211 Fab, Leukocyte surface antigen CD47, ... (8 entities in total)
• Functional Keywords: cd47, antibody, fab, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 62587.60

Authors

Wang, J.,Wang, R.,Jiao, S.,Wang, S.,Zhang, J.,Zhang, M.,Wang, M. (deposition date: 2022-04-16, release date: 2023-05-31, Last modification date: 2023-11-29)

• Primary citation: Wang, R.,Zhang, C.,Cao, Y.,Wang, J.,Jiao, S.,Zhang, J.,Wang, M.,Tang, P.,Ouyang, Z.,Liang, W.,Mao, Y.,Wang, A.,Li, G.,Zhang, J.,Wang, M.,Wang, S.,Gui, X.; Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment.; Theranostics, 13:148-160, 2023; PubMed: 36593962; DOI: 10.7150/thno.79367

Experimental method

X-RAY DIFFRACTION (2.6 Å)