7XJF
Crystal structure of 6MW3211 Fab in complex with CD47
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heavy chain of 6MW3211 Fab | polymer | 227 | 24472.5 | 1 | Homo sapiens (human) | ||
| 2 | B (B) | Light chain of 6MW3211 Fab | polymer | 214 | 23430.0 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | Leukocyte surface antigen CD47 | polymer | 116 | 13087.8 | 1 | UniProt (Q08722) Pfam (PF08204) | Homo sapiens (human) | Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6 |
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 5 | E, F (E, F) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 6 | G, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | I (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | J, K, L (A, B, C) | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
C: 1 - 116 (UniProt: Q08722)
| PDB | External Database | Details |
|---|---|---|
| Gly 15 | Cys 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60990.2 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1305.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 292.1 | |
| All* | Total formula weight | 62587.6 |
