7XI7
Human dihydrofolate reductase complexed with P39
Summary for 7XI7
| Entry DOI | 10.2210/pdb7xi7/pdb |
| Descriptor | Dihydrofolate reductase, 6-hexyl-5-phenyl-pyrimidine-2,4-diamine, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | human dhfr, dihydrofolate reductase, p39, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 22039.28 |
| Authors | Vanichtanankul, J.,Saeyang, T.,Kamchonwongpaisan, S.,Yuvaniyama, J.,Yuthavong, Y. (deposition date: 2022-04-12, release date: 2022-06-29, Last modification date: 2023-11-29) |
| Primary citation | Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Pengon, J.,Yuvaniyama, J.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17:1691-1702, 2022 Cited by PubMed: 35715223DOI: 10.1021/acschembio.1c00627 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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