7XE1

Crystal structure of LSD2 in complex with cis-4-Br-PCPA

Summary for 7XE1

• Entry DOI: 10.2210/pdb7xe1/pdb
• Descriptor: Lysine-specific histone demethylase 1B, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (9 entities in total)
• Functional Keywords: demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 182061.48

Authors

Niwa, H.,Sato, S.,Umehara, T. (deposition date: 2022-03-29, release date: 2022-09-14, Last modification date: 2023-11-29)

• Primary citation: Niwa, H.,Watanabe, C.,Sato, S.,Harada, T.,Watanabe, H.,Tabusa, R.,Fukasawa, S.,Shiobara, A.,Hashimoto, T.,Ohno, O.,Nakamura, K.,Tsuganezawa, K.,Tanaka, A.,Shirouzu, M.,Honma, T.,Matsuno, K.,Umehara, T.; Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2; Acs Med.Chem.Lett., 13:1485-1492, 2022; DOI: 10.1021/acsmedchemlett.2c00294

Experimental method

X-RAY DIFFRACTION (2.07 Å)