7XBK

Structure and mechanism of a mitochondrial AAA+ disaggregase CLPB

Summary for 7XBK

• Entry DOI: 10.2210/pdb7xbk/pdb
• EMDB information: 33104
• Descriptor: Isoform 2 of Caseinolytic peptidase B protein homolog, Unknown peptide, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: clpb, aaa-atpase, chaperone
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 685813.71

Authors

Wu, D.,Liu, Y.,Dai, Y.,Wang, G.,Lu, G.,Chen, Y.,Li, N.,Lin, J.,Gao, N. (deposition date: 2022-03-21, release date: 2023-01-25, Last modification date: 2023-02-22)

• Primary citation: Wu, D.,Liu, Y.,Dai, Y.,Wang, G.,Lu, G.,Chen, Y.,Li, N.,Lin, J.,Gao, N.; Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization.; Plos Biol., 21:e3001987-e3001987, 2023; PubMed: 36745679; DOI: 10.1371/journal.pbio.3001987

Experimental method

ELECTRON MICROSCOPY (3.7 Å)