7XBK

Structure and mechanism of a mitochondrial AAA+ disaggregase CLPB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030851	biological_process	granulocyte differentiation
A	0034605	biological_process	cellular response to heat
A	0039529	biological_process	RIG-I signaling pathway
A	0140374	biological_process	antiviral innate immune response
A	0140545	molecular_function	ATP-dependent protein disaggregase activity
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030851	biological_process	granulocyte differentiation
B	0034605	biological_process	cellular response to heat
B	0039529	biological_process	RIG-I signaling pathway
B	0140374	biological_process	antiviral innate immune response
B	0140545	molecular_function	ATP-dependent protein disaggregase activity
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030851	biological_process	granulocyte differentiation
C	0034605	biological_process	cellular response to heat
C	0039529	biological_process	RIG-I signaling pathway
C	0140374	biological_process	antiviral innate immune response
C	0140545	molecular_function	ATP-dependent protein disaggregase activity
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030851	biological_process	granulocyte differentiation
D	0034605	biological_process	cellular response to heat
D	0039529	biological_process	RIG-I signaling pathway
D	0140374	biological_process	antiviral innate immune response
D	0140545	molecular_function	ATP-dependent protein disaggregase activity
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030851	biological_process	granulocyte differentiation
E	0034605	biological_process	cellular response to heat
E	0039529	biological_process	RIG-I signaling pathway
E	0140374	biological_process	antiviral innate immune response
E	0140545	molecular_function	ATP-dependent protein disaggregase activity
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005758	cellular_component	mitochondrial intermembrane space
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030851	biological_process	granulocyte differentiation
F	0034605	biological_process	cellular response to heat
F	0039529	biological_process	RIG-I signaling pathway
F	0140374	biological_process	antiviral innate immune response
F	0140545	molecular_function	ATP-dependent protein disaggregase activity
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0030851	biological_process	granulocyte differentiation
G	0034605	biological_process	cellular response to heat
G	0039529	biological_process	RIG-I signaling pathway
G	0140374	biological_process	antiviral innate immune response
G	0140545	molecular_function	ATP-dependent protein disaggregase activity
H	0000166	molecular_function	nucleotide binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005758	cellular_component	mitochondrial intermembrane space
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0030851	biological_process	granulocyte differentiation
H	0034605	biological_process	cellular response to heat
H	0039529	biological_process	RIG-I signaling pathway
H	0140374	biological_process	antiviral innate immune response
H	0140545	molecular_function	ATP-dependent protein disaggregase activity
I	0000166	molecular_function	nucleotide binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005758	cellular_component	mitochondrial intermembrane space
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0030851	biological_process	granulocyte differentiation
I	0034605	biological_process	cellular response to heat
I	0039529	biological_process	RIG-I signaling pathway
I	0140374	biological_process	antiviral innate immune response
I	0140545	molecular_function	ATP-dependent protein disaggregase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	196
Details	Region: {"description":"Regulatory; slows ATPase and disaggregase activities","evidences":[{"source":"PubMed","id":"36170828","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36170828","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TTS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36170828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36745679","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7XBK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36745679","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XBK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---