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7XBK

Structure and mechanism of a mitochondrial AAA+ disaggregase CLPB

Functional Information from GO Data
ChainGOidnamespacecontents
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0030851biological_processgranulocyte differentiation
A0034605biological_processcellular response to heat
A0039529biological_processRIG-I signaling pathway
A0140374biological_processantiviral innate immune response
A0140545molecular_functionATP-dependent protein disaggregase activity
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005758cellular_componentmitochondrial intermembrane space
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0030851biological_processgranulocyte differentiation
B0034605biological_processcellular response to heat
B0039529biological_processRIG-I signaling pathway
B0140374biological_processantiviral innate immune response
B0140545molecular_functionATP-dependent protein disaggregase activity
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005758cellular_componentmitochondrial intermembrane space
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0030851biological_processgranulocyte differentiation
C0034605biological_processcellular response to heat
C0039529biological_processRIG-I signaling pathway
C0140374biological_processantiviral innate immune response
C0140545molecular_functionATP-dependent protein disaggregase activity
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005758cellular_componentmitochondrial intermembrane space
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0030851biological_processgranulocyte differentiation
D0034605biological_processcellular response to heat
D0039529biological_processRIG-I signaling pathway
D0140374biological_processantiviral innate immune response
D0140545molecular_functionATP-dependent protein disaggregase activity
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005758cellular_componentmitochondrial intermembrane space
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0030851biological_processgranulocyte differentiation
E0034605biological_processcellular response to heat
E0039529biological_processRIG-I signaling pathway
E0140374biological_processantiviral innate immune response
E0140545molecular_functionATP-dependent protein disaggregase activity
F0003674molecular_functionmolecular_function
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005758cellular_componentmitochondrial intermembrane space
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0030851biological_processgranulocyte differentiation
F0034605biological_processcellular response to heat
F0039529biological_processRIG-I signaling pathway
F0140374biological_processantiviral innate immune response
F0140545molecular_functionATP-dependent protein disaggregase activity
G0003674molecular_functionmolecular_function
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005758cellular_componentmitochondrial intermembrane space
G0016787molecular_functionhydrolase activity
G0016887molecular_functionATP hydrolysis activity
G0030851biological_processgranulocyte differentiation
G0034605biological_processcellular response to heat
G0039529biological_processRIG-I signaling pathway
G0140374biological_processantiviral innate immune response
G0140545molecular_functionATP-dependent protein disaggregase activity
H0003674molecular_functionmolecular_function
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005758cellular_componentmitochondrial intermembrane space
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0030851biological_processgranulocyte differentiation
H0034605biological_processcellular response to heat
H0039529biological_processRIG-I signaling pathway
H0140374biological_processantiviral innate immune response
H0140545molecular_functionATP-dependent protein disaggregase activity
I0003674molecular_functionmolecular_function
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005758cellular_componentmitochondrial intermembrane space
I0016787molecular_functionhydrolase activity
I0016887molecular_functionATP hydrolysis activity
I0030851biological_processgranulocyte differentiation
I0034605biological_processcellular response to heat
I0039529biological_processRIG-I signaling pathway
I0140374biological_processantiviral innate immune response
I0140545molecular_functionATP-dependent protein disaggregase activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:36170828, ECO:0007744|PDB:7TTR, ECO:0007744|PDB:7TTS
ChainResidueDetails
AVAL346
EPHE384
FVAL346
FPHE384
GVAL346
GPHE384
HVAL346
HPHE384
IVAL346
IPHE384
APHE384
BVAL346
BPHE384
CVAL346
CPHE384
DVAL346
DPHE384
EVAL346

site_idSWS_FT_FI2
Number of Residues36
DetailsBINDING: BINDING => ECO:0000269|PubMed:36170828, ECO:0000269|PubMed:36745679, ECO:0007744|PDB:7TTR, ECO:0007744|PDB:7TTS, ECO:0007744|PDB:7XBK
ChainResidueDetails
ALEU348
CGLU386
CHIS388
CARG620
DLEU348
DGLU386
DHIS388
DARG620
ELEU348
EGLU386
EHIS388
AGLU386
EARG620
FLEU348
FGLU386
FHIS388
FARG620
GLEU348
GGLU386
GHIS388
GARG620
HLEU348
AHIS388
HGLU386
HHIS388
HARG620
ILEU348
IGLU386
IHIS388
IARG620
AARG620
BLEU348
BGLU386
BHIS388
BARG620
CLEU348

site_idSWS_FT_FI3
Number of Residues54
DetailsBINDING: BINDING => ECO:0000269|PubMed:36745679, ECO:0007744|PDB:7XBK
ChainResidueDetails
AGLU383
BASP455
BGLY496
BALA561
CGLU383
CGLN385
CARG387
CASP455
CGLY496
CALA561
DGLU383
AGLN385
DGLN385
DARG387
DASP455
DGLY496
DALA561
EGLU383
EGLN385
EARG387
EASP455
EGLY496
AARG387
EALA561
FGLU383
FGLN385
FARG387
FASP455
FGLY496
FALA561
GGLU383
GGLN385
GARG387
AASP455
GASP455
GGLY496
GALA561
HGLU383
HGLN385
HARG387
HASP455
HGLY496
HALA561
IGLU383
AGLY496
IGLN385
IARG387
IASP455
IGLY496
IALA561
AALA561
BGLU383
BGLN385
BARG387

site_idSWS_FT_FI4
Number of Residues9
DetailsSITE: Cleavage; by PARL => ECO:0000269|PubMed:28288130
ChainResidueDetails
ACYS126
BCYS126
CCYS126
DCYS126
ECYS126
FCYS126
GCYS126
HCYS126
ICYS126

site_idSWS_FT_FI5
Number of Residues9
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
AALA589
BALA589
CALA589
DALA589
EALA589
FALA589
GALA589
HALA589
IALA589

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PDB entries from 2024-07-17

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