7XBB

Crystal structure of PDE4D catalytic domain complexed with compound 23a

Summary for 7XBB

• Entry DOI: 10.2210/pdb7xbb/pdb
• Descriptor: Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde4 inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 116637.35

Authors

Huang, Y.-Y.,Luo, H.-B. (deposition date: 2022-03-21, release date: 2022-07-06, Last modification date: 2023-11-29)

• Primary citation: Zhou, F.,Huang, Y.,Liu, L.,Song, Z.,Hou, K.Q.,Yang, Y.,Luo, H.B.,Huang, Y.Y.,Xiong, X.F.; Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.; Biochem Pharmacol, 202:115123-115123, 2022; PubMed: 35688178; DOI: 10.1016/j.bcp.2022.115123

Experimental method

X-RAY DIFFRACTION (2.10000900931 Å)