7XBB
Crystal structure of PDE4D catalytic domain complexed with compound 23a
Summary for 7XBB
Entry DOI | 10.2210/pdb7xbb/pdb |
Descriptor | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde4 inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 116637.35 |
Authors | Huang, Y.-Y.,Luo, H.-B. (deposition date: 2022-03-21, release date: 2022-07-06, Last modification date: 2023-11-29) |
Primary citation | Zhou, F.,Huang, Y.,Liu, L.,Song, Z.,Hou, K.Q.,Yang, Y.,Luo, H.B.,Huang, Y.Y.,Xiong, X.F. Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects. Biochem Pharmacol, 202:115123-115123, 2022 Cited by PubMed: 35688178DOI: 10.1016/j.bcp.2022.115123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.10000900931 Å) |
Structure validation
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